Arun Srivastava, Ph.D.
George H. Kitzman Professor of Genetics
Pediatrics and Molecular Genetics & Microbiology
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Arun Srivastava, Ph.D. |
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Molecular correlates of human parvoviruses, and recombinant parvovirus vectors for human gene therapy For the past 30 years, Dr. Srivastava's research has been focused on the following two parvoviruses, the non-pathogenic adeno-associated virus (AAV), and a common human pathogen, the parvovirus B19, and the development of recombinant parvovirus vectors in human gene therapy. His laboratory has made seminal contributions to the field of parvoviruses, which include: identification of cellular co-receptors for AAV2 [A], AAV3 [B] as well as parvovirus B19 [C]; elucidation of various steps involved in parvovirus trafficking in the cell and nuclear transport; identification of cellular proteins involved in the regulation of AAV DNA replication and encapsidation; development of recombinant AAV and parvovirus B19 vectors; and transgenic and knockout mouse models to study parvovirus-induced pathogenicity, and the use of parvovirus vectors for gene transfer and gene therapy. More recently, the next generation of recombinant AAV vectors have been developed in his laboratory that transduce cells and tissues more efficiently at lower vector doses [D]. In collaboration with Dr. Roland Herzog's laboratory, he has developed strategies to achieve therapeutic levels of coagulation factors at reduced vector doses for the potential gene therapy of hemophilia [E,F]. The current emphasis is on developing recombinant parvovirus vectors for gene therapy for genetic diseases such as β-thalassemia and sickle cell disease, and malignant disorders such as hepatoblastoma and hepatocellular carcinoma.
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Status: Possibly Accepting New Students This Year Contact Information: office: CGRC Room 492-A lab: CGRC Rooms 485-G/490-B phone: 352-273-8259 email: aruns@peds.ufl.edu Home Page Biography: Dr. Srivastava is Chief of Division of Cellular & Molecular Therapy in the Departments of Pediatrics, and Molecular Genetics & Microbiology, and Powell Gene Therapy Center. He also serves as Assistant Director of the UF General Clinical Research Center. He received his PhD degree from the Indian Institute of Science in Bangalore, India. After completing his postdoctoral training at the Memorial Sloan-Kettering Cancer Center in New York, he worked as a Research Associate at UF. For nearly two decades, he was on the faculty at Indiana University School of Medicine in Indianapolis, where he rose to the rank of Professor. He was recruited back to the UF in 2004. In the past three decades, he has mentored 6 Clinical Fellows and 30 Postdoctoral Fellows. Two students have graduated with MS degrees, and 6 students have received their PhD degrees from his laboratory. His research activities are currently supported by grants from the National Institutes of Health and the Bayer Hemophilia Program. He has also been awarded 3 US Patents on his research on human parvoviruses and their potential use as vectors in human gene therapy. He currently serves on two NIH Study Sections as well as on the Editorial Boards of Journal of Virology, Gene Therapy, Human Gene Therapy, Recent Patents on DNA and Gene Sequences, Gene Therapy and Molecular Biology, and Journal of Chinese Integrative Medicine. He has published 142 research articles, mostly on human parvoviruses, in peer-reviewed journals, reviews, and book chapters. |
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