12/1/09 - Jennifer Thompson presented Kolandaivelu, S. et al. (2009) AIPL1, a protein associated with childhood blindness, interacts with α-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly.
J. Biol. Chem. 284, 30853-30861
11/24/09 - River Ybarra presented Grassinger, J. et al. (2009) Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with α9β1 and α4β1 integrins.
Blood 114, 49-59
11/17/09 - Mukundh Balasubramanian presented Yang, X-c. et al. (2009) FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3'end processing of histone pre-mRNA's.
Molecular Cell 36, 267-278
11/10/09 - Balu Avvaru his research in the McKenna Lab
"Insights into the catalytic mechanism of human carbonic anhydrase II."
10/27/09 - Ryan Skehan presented Kraft, C. et al. (2008) Mature ribosomes are selectively degraded upon staration by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease.
Nature Cell Biol. 10, 602-610
10/20/09 - Ankita Chiraniya presented Gafni, J. et al. (2009) Calpain-1 cleaves and activates caspase-7.
J. Biol. Chem. 284, 25441-25449
10/13/09 - Kavitha Gnanasambandan presented Mukherjee, K. et al. (2008) CASK functions as a Mg2+-independent neurexin kinase.
Cell 133, 328-339.
10/6/09 - Bala Venkatakrishnan Wu, Y.I. et al. (2009) A genetically encoded photoactivatable Rac controls the motility of living cells.
Nature 461, 104-108
9/29/09 - Danel Gibson presented his work in the
Schultz Lab "The Molecular Biology of Corneal Fibrosis"
9/22/09 - Tina Halder presented Sapparapu, G. et al. (2009) Antigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chain.
J. Biol. Chem. 284, 24622-24633
9/15/09 - Lisa Dyer presented Nakatani, J. et al. (2009) Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism.
Cell 137, 1235-1246.
9/8/09 - Katherine Sippel her research in the McKenna Lab
"Mycoplasma p37: The tale of a protein in search of an identity."
9/1/08 - Dr. Ben Dunn presented his research
"The ABCs of HIV-1 Protease".
Spring 2009 Presentations
Topic: Epigenetics - Nature vs. Nurture
4/28/09 - Tolunay Beker presented Xiao, A. et al. (2009) WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Nature 457, 57-62.
4/21/09 - Mukundh Balasubramanian presented McGowan, P.O.et al. (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.
Nature Neuroscience 12, 342-348.
4/14/09 - Randy Jirtle, Ph.D., Professor, Duke University School of Medicine, presented his research
"Epigenetics: the Inextricable Link Between Nature and Nurture".
4/7/09 - Jennifer Thompson presented Xie, W. et al. (2009) Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.
Mol. Cell 33, 417-427.
3/31/09 - River Ybarra presented Colmone, A. et al. (2008) Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoetic progenitor cells.
Science 322, 1861-1865.
3/24/09 - Ryan Skehan presented Lubin, F.D. et al. (2008) Epigenetic regulation of bdnf gene transcription in the consolidation of fear memory.
J. Neuroscience 28, 10576-10586.
3/17/09 - Jeanne Quirit presented Mammoto, A. et al. (2009) A mechanoselective transcriptional mechanism that controls angiogenesis.
Nature 457, 1103-1109.
3/10/09 - Lauren Drouin presented Silva, L. et al. (2008) Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation.
PLOS Pathogens 4(5), e1000071.
3/3/09 - Lawrence Tartaglia presented Mikkelsen, T.S. et al. (2008) Dissecting direct reprogramming through integrative genomic analysis.
Nature 454, 49-55.
2/24/09 - Mollie Martin presented Lujambio, A. (2008) A microRNA DNA methylation signature for human cancer metastasis.
PNAS 105, 13556-13561.
2/17/09 - Sayak Mitter presented Varambally, S. et al. (2008) Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer.
Science 322, 1695-1699.
2/10/09 - Ying Li presented Han, X. et al. (2008) Tethering by lamin A stabilizes and targets the ING1 tumor suppressor.
Nature Cell Biology 10, 1333-1340.
2/3/09 - Daniel Gibson presented Weaver, I.C.G. et al. (2008) Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: Altering epigenetic marking later in life.
J. Neuroscience 25, 11045-11054.
1/27/09 - Kavitha Gnanasambandan presented Hansen, K.H. et al. (2008) A model for transmission of the H3K27me3 epigenetic mark.
Nature Cell Biology 10, 1291-1300.
1/20/09 - Ankita Chiraniya presented Alenghat, T. et al. (2008) Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology.
Nature 456, 997-1000.
1/13/09 - Robert Ng presented Vincenz, C. and Kerppola, T.K. (2008) Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences.
PNAS 105, 16572-16577.
1/6/09 - Bala Venkatakrishnan presented Meissner, A. et al. (2008) Genome-scale DNA methylation maps of pluripotent and differentiated cells.
Nature 454, 766-770.
Fall 2008 Presentations
Topic: HIV and Viral Assembly
12/9/08 - Balendu Avvaru presented Kaganovich, D., Kopito, R. and Frydman, J. (2008) Misfolded proteins partition between
two distinct quality control compartments.
Nature 454, 1089-1096.
11/25/08 - Ada Ao presented Mercer J. and Helenius, H. (2008) Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells.
Science 320, 531-535.
11/18/08 - Lisa Dyer presented Wen, L. et al. (2008) Innate immunity and intestinal microbiata in the development of Type 1 diabetes.
Nature 455, 1109-1113.
11/13/08 - Wesley Sundquist, Ph.D., Professor, University of Utah, presented his research
"Structural Biology and Biochemistry of HIV Assembly and Budding".
11/4/08 - Suzanne Farver presented Bartonova, V. et al. (2008) Residues in the HIV-1 capsid assembly inhibitor binding site are essential
for maintaining the assembly competent quarternary structure of the capsid protein.
J. Biol. Chem. Article in Press
10/28/08 - Bing Yao presented Rauch, S. et al. (2008) Human Immunodeficiency Virus Type 1 Nef Recruits the Guanine Exchange Factor Vav1 via an Unexpected
Interface into Plasma Membrane Microdomains for Association with p21-Activated Kinase 2 Activity.
Journal of Virology 82, 2918-2929.
10/21/08 - Katherine Sippel presented Wang, J.-H. et al. (2008) Macropinocytosis and cytoskeleton contribute to dendritic cell-mediated HIV-1 transmission to CD4+ cells.
Virology Article in Press
10/14/08 - Brittney Gurda presented Trajkovic, K. et al. (2008) Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes.
Science 319, 1244-1247.
10/7/08 - Carolina Pardo presented Carlton, J.G. et al. (2008) Differential Requirements for Alix and ESCRT-III in Cytokinesis and HIV-1 release.
PNAS 105, 10541-10545
9/30/08 - Sushama Kamarajugadda presented Strasner, A.B. et al. (2008) The Src Kinase Lck Facilitates Assembly of HIV-1 at the Plasma Membrane.
J. Immuno. 181, 3706 -3713.
9/23/08 - Dr. Ben Dunn presented his research
"Global Infectious Diseases: HIV Protease Sequence Variability and Drug Resistance".
9/9/08 - Amanda Welch presented Dantas, G. et al. (2008) Bacteria subsisting on antibiotics.
Science 320, 100 - 103.
9/2/08 - John Domsic presented Ushioda, R. et al. (2008) ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.
Science 321, 569 - 572.
Spring 2008 Presentations
Topic: Antimicrobial Peptides
4/22/08 - Ying Li presented Corbin, B.D. et al. (2008) Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses.
Science 319, 962 - 965.
4/15/08 - Guest speaker Dr. Michael Zasloff presented his research
"So why don't I get an infection when I bite my tongue: The silent role of innate immunity in human health".
4/1/08 - Bing Yao presented Greten, F.R. et al. (2007) NF-κB is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ.
Cell 130, 918-931.
3/25/08 - Sujata Halder presented Nakatsukasa, K. et al. (2008) Dissecting the ER-associated Degradation of a Misfolded Polytopic Membrane Protein.
Cell 132, 102-112.
3/18/08 - Dan Gibson presented Karnik, S.K. et al. (2007) Menin Controls Growth of Pancreatic β-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus.
Science 318, 806 - 809.
3/4/08 - Judy Hwang presented Ryu, J.-H. et al. (2008) Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila.
Science 319, 777 - 782.
2/26/08 - Tolunay Beker presented Foster, S.L. et al. (2007) Gene-specific control of inflammation by TLR-induced chromatin modifications.
Nature 447, 972-978.
2/19/08 - Suzanne Farver presented Pistolesi, S. et al. (2007) Membrane Insertion and Bilayer Perturbation by Antimicrobial Peptide CM15.
Biophys. J. 93, 1651-1660.
2/12/08 - Lisa Dyer presented Overholtzer, M. et al. (2007) A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion.
Cell 131, 966-979.
2/05/08 - Carolina Pardo presented Lande, R. et al. (2007) Plasmacytoid dendritic cells
sense self-DNA coupled with antimicrobial peptide.
Nature 449, 564-569.
1/22/08 - Katherine Sippel presented Nishida, N. et al. (2007) Interaction of Magainin-PGLa Peptide with Membranes:
Insight into the Mechanism of Synergism.
Biochemistry 46, 14284-14290.
1/15/08 - Justin Bickford presented Gupta, M. and Copeland, P.R. (2007) Functional Analysis of the Interplay between Translation Termination,
Selenocytein Codon Context, and Slenocystein Insertion Sequence-binding Protein 2.
J. Biol. Chem. 282, 36797-36807.
1/08/08 - Santhi Pondugula presented Takahashi, K. et al. (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors.
Cell 131, 861-872.
Fall 2007 Presentations
12/4/07 - Brian Fuller presented Pentcheva-Hong, T. et al. (2007) Programmed Death-1 Concentration at the Immunological Synapse is Determined by Ligand Affinity and Availability.
Proc. Natl. Acad. Sci. USA 104, 17,765-17,770
11/27/07 - Nan Su presented Dong, J. et al. (2007) Elucidation of a Universal Size-control Mechanism in Drosophila and Mammals.
Cell 130, 1120-1133
11/20/07 - Ada Ao presented Arockia Jeyaprakash, A. et al. (2007) Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together.
Cell 131, 271-285
11/13/07 - John Domsic presented Kang, B.H. et al. (2007) Regulation of Tumor Cell Mitochondrial Homeostasis by an Organelle-Specific Hsp90 Chaperone Network.
Cell 131, 257-270
11/6/07 - Altin Gjymishka presented a talk on his research in the Kilberg Lab entitled "Distinct Transcriptional Regulation of Human
Neutral Amino Acid Transporter SNAT2 by Endoplasmic Reticulum Stress and Amino Acid Limitation".
10/29/07 - Brittney Gurda presented Luke, C.J. et al. (2007) An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal Injury
Cell 130, 1108-1119
10/23/07 - Zhuo Zhou presented Cheah, M.T. et al. (2007) Control of Alternative RNA Splicing and Gene Expression by Eukaryotic Riboswitches.
Nature 447, 497-500.
10/16/07 - Melissa Marzahn presented her research in the Dunn Lab entitled
"Characterization of Plasmepsins from the Malaria Parasite Plasmodium falciparum".
10/9/07 - Suhashni Gopalakrishnan presented Denchi, E.L. and de Lange, T. (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Nature 448, 1068-1071.
10/2/07 - Amanda Welch presented Ortlund, E.A. et al. (2007) Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis.
Science 317, 1544-1548.
9/25/07 - Nicolette Case presented Kovtun, I.V. et al. (2007) OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.
Nature 447, 447-45.
9/18/07 - Marsha Bush presented Nakamura ,T. et al. (2007) Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts.
Cell 130, 811-823.
9/11/07 - Jesse Kay presented Schug, T.T. et al. (2007) Opposing Effects of Retinoic Acid on Cell Growth Result from Alternate Activation of Two Different Nuclear Receptors.
Cell 129, 723-733.
