Transcriptionally active chromatin regions tend to be hyperacetylated and hypomethylated.  If a region of DNA or a gene is destined for silencing, chromatin remodeling enzymes such as histone deacetylases and ATP-dependent chromatin remodelers likely begin the gene silencing process.  One or more of these activities may recruit DNA methyltransferase resulting in DNA methylation, followed finally by recruitment of the methyl-CpG binding proteins.  The region of DNA will then be heritably maintained in an inactive state.