The DNA Methylation Machinery Interacts with the Histone Modification Machinery

               DNMTs interacts with:

• Histone deacetylases (HDACs)
• Histone methylases (HMTases)
• ATP-dependent chromatin remodelers
• Chromatin structural proteins (HP1 family)

Cooperative and self-reinforcing organization of the chromatin & DNA-modifying machinery responsible for gene silencing in normal & malignant cells