2) DNA Methylation and Cancer.

Relevant publications:

1. Robertson, KD and Wolffe, AP. DNA methylation in health and disease. Nature Rev.Genet. 1:11-19, 2000.  (click to view as PDF)

2. Robertson, KD. DNA methylation, methyltransferases, and cancer. Oncogene 20:3139-3155, 2001.  (click to view as PDF)

3. Robertson, KD. DNA methylation and human disease. Nature Rev. Genet. 6:597-610, 2005.  (click to view as PDF)

4. Robertson, KD and Jones, PA. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol. Cell. Biol. 18(11):6457-6473, 1998.  (click to view as PDF)

5. Robertson, KD. Uzvolgyi, E, Liang, G, Talmadge, C, Sumegi, J, Gonzales, FA, Jones, PA. The human DNA methyltransferases (DNMTs) 1, 3a, and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 27(11):2291-2298, 1999.  (click to view as PDF)

6. Robertson, KD and Jones, PA. DNA methylation and gene control:  Past, present, and future directions. Carcinogenesis 21(3):461-467, 2000.  (click to view as PDF)

7. Robertson, KD, Keyomarsi, K, Gonzales, FA, Velicescu, M, Jones, PA. Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a, and 3b during the G₀/G₁ to S phase transition in normal and tumor cells. Nucleic Acids Res. 28(10):2108-2113, 2000.  (click to view as PDF)

8. Chan, ATC, Tao, Q, Robertson, KD, Flinn, IW, Mann, RB, Klencke, B, Kwan, WH, Leung, TW-T, Johnson, PJ, Ambinder, RF. Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors in patients. J. Clin. Oncol. 22(8):1373-1381, 2004.

9. Yokochi, T and Robertson, KD. Doxorubicin inhibits DNMT1 resulting in conditional apoptosis. Mol. Pharmacol. 66:1415-1450, 2004.  (click to view as PDF)

10. Brown, KD, Robertson, KD. DNMT1 knockout delivers a strong blow to genome stability and cell viability. Nature Genet. 39(3): 289-290, 2007.  (click to view as PDF)

11. Zhong, S, Fields, CR, Su, N, Pan, Y-X, Robertson, KD. Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. Oncogene 26(18): 2621-2634, 2007.  (click to view as PDF)

12. Palii, SS, Robertson, KD. Epigenetic control of tumor suppression. Crit. Rev. Euk. Gene Exp. 17(4): 295-316, 2007.  (click to view as PDF)

13. Van Emburgh, BO, Robertson, KD. DNA methyltransferases and methyl-CpG binding proteins as multi-functional regulators of chromatin structure and development in mammalian cells, In Epigenetics, pp. 23-62 (J. Tost, ed.). Caister Academic Press, 2008.

14. Palii, SS, Van Emburgh, BO, Sankpal, UT, Brown KD, Robertson, KD. DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-azadC) induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases (DNMTs) 1 and 3B. Moll. Cell. Biol. 28(2): 752-771, 2008.  (click to view as PDF)

15. Jin, B, Tao, Q, Peng, J, Soo, HM, Wu, W, Ying, J, Fields, CR, Delmas, AL, Liu, X, Qiu, J, Robertson, KD. DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis, and immune function. Hum. Mol. Genet. 17(5): 690-709, 2008.  (click to view as PDF)

16. Kim, T-Y, Zhong, S, Fields, CR, Kim, JH, Robertson, KD. Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res. 66(15): 7490-7501, 2006.  (click to view as PDF)

17. Ai, L, Tao, Q, Zhong, S, Fields, CR, Kim, W-J, Lee, MW, Cui, Y, Brown, KD, and Robertson, KD. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis 27(7): 1341-1348, 2006.  (click to view as PDF)