3) Connections between DNA Methylation and Chromatin Remodeling.

Relevant publications:

1. Robertson, KD and Jones, PA. DNA methylation and gene control:  Past, present, and future directions. Carcinogenesis 21(3):461-467, 2000.  (click to view as PDF)

2. Robertson, KD, Ait-Si-Ali, S, Yokochi, T, Wade, PA, Jones, PL, Wolffe, AP. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nature Genet. 25:338-342, 2000.

3. Robertson, KD. DNA methylation and human disease. Nature Rev. Genet. 6:597-610, 2005.  (click to view as PDF)

4. Robertson, KD. DNA methylation and chromatin structure: Unraveling the tangled web. Oncogene 21:5361-5379, 2002.  (click to view as PDF)

5. Geiman, TM and Robertson, KD. Chromatin remodeling, histone modifications, and DNA methylation – how does it all fit together? J. Cell. Biochem. 87:117-125, 2002.

6. Robertson, KD. Relationships between DNA methylation, histone modification, and chromatin structure. In DNA Methylation and Cancer Therapy, (M. Szyf, ed.) Landes Bioscience, 2003.

7. Ling, Y, Sankpal, UT, Geiman, TM, Robertson, AK, McNally, JG, Karpova, T, and Robertson, KD. Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 32(2):598-610, 2004.  (click to view as PDF)

8. Geiman, TM, Sankpal, UT, Robertson, AK, Zhao, Y, Zhao, Y, and Robertson, KD. DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem. Biophys. Res. Comm. 318(2):544-555, 2004.  (click to view as PDF)

9. Geiman, TM, Sankpal, UT, Robertson, AK, Chen, Y, Mazumdar, M, Heale, JT, Schmiesing JA, Kim, W, Yokomori, K, Zhao, Y, and Robertson, KD. Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res. 32(9):2716-2729, 2004.  (click to view as PDF)

10. Robertson, AK, Geiman, TM, Sankpal, UT, Hager, GL, Robertson, KD. Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro. Biochem. Biophys. Res. Comm. 322:110-118, 2004.  (click to view as PDF)

11. Palii, SS, Robertson, KD. Epigenetic control of tumor suppression. Crit. Rev. Euk. Gene Exp. 17(4): 295-316, 2007.  (click to view as PDF)

12. Van Emburgh, BO, Robertson, KD. DNA methyltransferases and methyl-CpG binding proteins as multi-functional regulators of chromatin structure and development in mammalian cells, In Epigenetics, pp. 23-62 (J. Tost, ed.). Caister Academic Press, 2008.

13. Jin, B, Tao, Q, Peng, J, Soo, HM, Wu, W, Ying, J, Fields, CR, Delmas, AL, Liu, X, Qiu, J, Robertson, KD. DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis, and immune function. Hum. Mol. Genet. 17(5): 690-709, 2008.  (click to view as PDF)