Michael S. Kilberg, PUBLICATIONS

REFEREED PUBLICATIONS:

117. Shan, J., Ord, D., Ord, T., and Kilberg, M.S. (2009) Elevated ATF4 Expression, in the Absence of Other Signals, is Sufficient for Transcriptional Induction via C/EBP-ATF Response Elements, J. Biol. Chem., 284, 21241-21248.

116. Su, N., Thiaville, M.M., Awad, K., Gjymishka, A., Brant, J.O., Yang, T.P., and Kilberg, M.S. (2009) Protein or Amino Acid Deprivation Differentially Regulates the Hepatic FOXA Genes Through an ATF4-Independent Pathway, Hepatology, 50, 282-290.

115. Palii, S.S., Kays, C.E., Deval, C., Bruhat, A., Fafournoux, and Kilberg, M.S. (2009) Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation. Amino Acids, 37, 79-88.

114. Gjymishka, A., Su, N., and Kilberg, M.S. (2009) Transcriptional Induction of the Human Asparagine Synthetase Gene During the Unfolded Protein Response Does Not Require the ATF6 and IRE1/XBP1 Arms of the Pathway. Biochem. J., 417, 695-703.

113. Su, N. and Kilberg, M. S. (2008) C/EBP homology protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-Dependent Induction of the Asparagine Synthetase Gene, J. Biol. Chem., 283, 35106-35117.

112. Thiaville, M.M., Dudenhausen, E.E., Awad, K.S., Zhong, C., and Kilberg, M.S. (2008) Activated Transcription Via Mammalian Amino Acid Response Elements Does Not Require Enhanced Recruitment of the Mediator Complex. Nuc. Acids Res., 36, 5571-5580.

111. Gjymishka, A., Palii, S.S., Shan, J., and Kilberg, M.S. (2008) Despite Increased ATF4 Binding at the C/EBP-ATF Composite Site Following Activation of the Unfolded Protein Response, System A Transporter 2 (SNAT2) Transcription Activity is Repressed in HepG2 Cells, J. Biol. Chem., 283, 27736-27747.

110. Abbatiello, S.E., Pan, Y-X., Zhou, M., Wayne, A.S., Veenstra, T.D., Hunger, S.P., Kilberg, M.S., Eyler, J.R., Richards, N.G., Conrads, T.P. (2008) Mass Spectrometric Quantification of Asparagine Synthetase in Circulating Leukemia Cells from Acute Lymphoblastic Leukemia Patients. J. Proteomics., 71, 61-70.

109. Thiaville, M.M., Pan, Y-X., Gjymishka, A., Zhong, C., Kaufman, R.J., and Kilberg, M.S. (2008) MEK Signaling is Required for Phosphorylation of eIF2a Following Amino Acid Limitation of HepG2 Human Hepatoma Cells. J. Biol. Chem., 283, 10848-10857.

108. Aiken, K.J., Bickford, J.S., Kilberg, M.S., and Nick, H.S. (2008) Metabolic Regulation of Manganese Superoxide Dismutase Expression via Essential Amino Acid Deprivation. J. Biol. Chem., 283, 10252-10263.

107. Thiaville, M.M., Dudenhausen, E.E., Zhong, C., Pan, Y-X., and Kilberg, M.S. (2008) Deprivation of Protein or Amino Acid Induces C/EBPb Synthesis and Binding to Amino Acid Response Elements, but its Action is Not an Absolute Requirement for Enhanced Transcription. Biochem. J., 410, 473-484.

106. Su, N., Pan, Y-X., Zhou, M., Harvey, R.C., Hunger, S.P., and Kilberg, M.S. (2008) Correlation between Asparaginase Sensitivity and Asparagine Synthetase Protein Content, but not mRNA, in Acute Lymphoblastic Leukemia Cell Lines, Pediatric Blood & Cancer, 50, 274-279.

105. Gutierrez, J.A., Pan, Y-X., Koroniak, L., Hiratake, J., Kilberg, M.S., and Richards, N.G.J. (2007) An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase Resistant Leukemia Cell Line. Chem. & Biol., 13, 1339-1347.

104. Pan, Y-X., Chen, C., Thiaville, M.M., and Kilberg, M.S. (2007) Activation of the ATF3 Gene through a Coordinated Amino Acid-Sensing Response Program that Controls Transcriptional Regulation of Responsive Genes Following Amino Acid Limitation. Biochem. J., 401, 299-307.

103. K ilberg, M.S. (2006) Amino Acid-Dependent Signal Transduction for Control of Transport and Metabolism. Acta Biomed., 77(Suppl. 3), 18-20.

102. Chen, H. and Kilberg, M.S. (2006) Alignment of the Transcription Start Site Coincides with Increased Transcriptional Activity from the Human Asparagine Synthetase Gene Following Amino Acid Deprivation. J. Nutr., 136, 2463-2467.

101. Palii, S.S., Thiaville, M.M., Pan, Y-X., Zhong, C., and Kilberg, M.S. (2006) Characterization of the Amino Acid Response Element Within the Human SNAT2 System A Transporter Gene. Biochem. J., 395, 517-527.

100. Chen C., Dudenhausen, E.E., Chen, H., Pan, Y-X., Gjymishka, A., and Kilberg, M.S. (2005) Amino Acid Limitation Induces Transcription from the Human C/EBPb Gene Via an Enhancer Activity Located Downstream of the Protein Coding Sequence. Biochem. J., 391, 649-658.

99. Pan, Y-X., Chen, H., and Kilberg, M.S. (2005) Interaction of RNA-Binding Proteins HuR and AUF1 with the human ATF3 mRNA 3¢ UTR Regulates its Amino Acid Limitation-Induced Stabilization. J. Biol. Chem., 280, 34609-34616.

98. Chen, H., Pan, Y., Dudenhausen, E.E., and Kilberg, M.S. (2004) Amino Acid Deprivation Induces the Transcription Rate of the Human Asparagine Synthetase Gene Through a Timed Program of Expression and Promoter Binding of Nutrient-Responsive bZIP Transcription Factors as well as Localized Histone Acetylation. J. Biol. Chem., 279, 50829-50839.

97.Chen, C., Dudenhausen, E.E., Pan, Y., Zhong, C., and Kilberg, M.S. (2004) Human CCAAT/Enhancer-Binding Protein Beta (C/EBPb) Gene Expression is Activated By Endoplasmic Reticulum Stress through an Unfolded Protein Response Element Downstream of the Protein Coding Sequence. J. Biol. Chem., 279, 27948-27956.

96. Leung-Pineda, V., Chen, H., and Kilberg, M.S. (2004) Induction of p21 and p27 Expression by Amino Acid Deprivation of HepG2 Human Hepatoma Cells. Biochem. J., 379, 79-88.

95. Palii, S.S., Chen. H., and Kilberg, M.S. (2004) Transcriptional Control of the Human SNAT2 System A Transporter Gene by Amino Acid Availability is Mediated by an Intronic Element. J. Biol. Chem., 279, 3463-3471.

94. Pan, Y.-X., Chen, H., Siu, F., and Kilberg, M.S. (2003) Amino Acid Deprivation and Endoplasmic Reticulum Stress Induce Expression of Multiple Activating Transcription Factor-3 mRNA Species That, When Over-expressed in HepG2 Cells, Modulate Transcription by the Human Asparagine Synthetase Promoter. J. Biol. Chem., 278, 38402-38412.

93. Burkhardt, B.R., Loiler, S.A., Anderson, J.A., Kilberg, M.S., Crawford, J.M., Flotte, T.R., Goudy, K.S., Ellis, T.M., and Atkinson, M. (2003) Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells. Ann. N. Y. Acad. Sci., 1005, 237-241.

92. Weiss, M.D., Derazi, S., Rossignol, C., Varoqui, H., Erickson, J.D., Kilberg, M.S., and Anderson, K.J. (2003) Ontogeny of the neutral amino acid transporter SAT1/ATA1 in rat brain. Dev. Brain Res., 143, 151-159.

91. Zhong, C., Chen, C., and Kilberg, M.S. (2003) Characterization of the Nutrient Sensing Response Unit in the Human Asparagine Synthetase Promoter. Biochem. J., 372, 603-609.

90. Chang, S.-H., Garcia, J., Melendez, J.A., Kilberg, M.S., and Agarwal, A. (2003) Heme Oxygenase-1 Gene Induction by Glucose Deprivation is Mediated by Reactive Oxygen Species via the Mitochondrial Electron Transport Chain. Biochem. J., 371, 877-885.

89.Bruhat, A., Averous, J., Carraro, V., Zhong, C., Reimold, A.M., Kilberg, M.S., and Fafournoux, P. (2002) Differences in the Molecular Mechanisms Involved in the Transcriptional Activation of CHOP And Asparagine Synthetase in Response to Amino Acid Deprivation and Activation of the Unfolded Protein Response, J. Biol. Chem., 277, 48107-48114.

88. Bain, P.J., LeBlanc-Chaffin, R., Chen, H., Palii, S.S., Leach, K.M., and Kilberg, M.S. (2002) The Mechanism for Transcriptional Activation of the Human ATA2 Transporter Gene by Amino Acid Deprivation is Different Than That for Asparagine Synthetase, J. Nutr., 132, 3023-3029.

87. Yang, W. and Kilberg, M.S. (2002) Biosynthesis, Intracellular Targeting, and Degradation of the EAAC1 Glutamate/Aspartate Transporter in C6 Glioma Cells, J. Biol. Chem., 277, 38350-38357.

86. Siu, F., Bain, P.J., LeBlanc-Chaffin, R., Chen, H., and Kilberg, M.S. (2002) ATF4 is a Mediator of the Nutrient Sensing Response Pathway that Activates the Human Asparagine Synthetase Gene. J. Biol. Chem., 277, 24120-24127.

85. Cramer, S., Beveridge, M., Kilberg, M. and Novak, D. (2002) Physiological Importance of System A-Mediated Amino Acid Transport to Rat Fetal Development. Am. J. Physiol. 282, C153-C160.

84. Leung-Pineda, V. and Kilberg, M.S. (2002) Role of Sp1 and Sp3 in the Nutrient-Regulated Expression of the Human Asparagine Synthetase Gene. J. Biol. Chem., 277, 16585-16591.

83. Chang, S.-H., Barbosa-Tessmann, I., Chen, C., Kilberg, M.S., and Agarwal, A., (2002) Glucose Deprivation Induces Heme Oxygenase-1 Gene Expression by a Pathway Independent of the Unfolded Protein Response. J. Biol. Chem., 277, 1933-1940.

82. Siu, F., Chen, C., Zhong, C., and Kilberg, M.S. (2001) CCAAT/Enhancer-Binding Protein Beta (C/EBPb) is a Mediator of the Nutrient Sensing Response Pathway that Activates the Human Asparagine Synthetase Gene. J. Biol. Chem., 276, 48100-48107.

81. Weiss, M.D., Derazi, S., Kilberg, M.S., and Anderson, K.J. (2001) Ontogeny and Localization of the Amino Acid Transporter ASCT1 in Rat Brain. Dev. Brain Res., 130, 183-190.

80. Aslanian, A.M. and Kilberg, M.S. (2001) Multiple Adaptive Mechanisms Affect Asparagine Synthetase Substrate Availability in Asparaginase Resistant Molt-4 Human Leukemia Cells. Biochem. J., 358, 59-67.

79. Aslanian, A.M., Fletcher, B.S., and Kilberg, M.S. (2001) Asparagine Synthetase Expression Alone is Sufficient to Induce Asparaginase Resistance in Molt-4 Human Leukemia Cells. Biochem. J., 357, 321-328.

78. Barbosa-Tessmann, I.P., Chen, C., Zhong, C., Siu, F., Schuster, S.M., Nick, H.S., and Kilberg, M.S. (2000) Activation of the Human Asparagine Synthetase Gene by the Amino Acid Response and the Endoplasmic Reticulum Stress Response Pathways Occurs by Common Genomic Elements. J. Biol. Chem., 275, 26976-26985.

77. Barbosa-Tessmann, I.P., Chen, C., Zhong, C., Schuster, S.M., Nick, H.S., and Kilberg, M.S. (1999) Activation of the Unfolded Protein Response Pathway Induces Human Asparagine Synthetase Gene Expression. J. Biol. Chem., 274, 31139-31144.

76. Matthews, J.C., Beveridge, M.J., Dialynas, E., Bartke, A., Kilberg, M.S., and Novak, D.A., (1999) Placental Anionic and Cationic Amino Acid Transporter Expression in Growth Hormone Overexpressing, Null IGF-II, or Null IGF-I Receptor Mice. Placenta, 20, 639-650.

75. Barbosa-Tessmann, I.P., Leung Pineda, V., Nick, H.S., Schuster, S.M., and Kilberg, M.S. (1999) Transcriptional Regulation of the Human Asparagine Synthetase Gene by Carbohydrate Availability. Biochem. J., 339, 151-158.

74. Matthews, J.C., Beveridge, M.J., Malandro, M.S., Rothstein, J.D., Campbell-Thompson, M., Verlander, J., Kilberg, M.S., and Novak, D.A., (1998) Activity and Protein Localization of Multiple Glutamate Transporters in Gestation Day 14 versus Day 20 Rat Placenta. Am. J. Physiol., 274, C603-C614.

73. Matthews, J.C., Beveridge, M.J., Malandro, M.S., Kilberg, M.S., and Novak, D.A., (1998) Response of Placental Amino Acid Transport to Gestational Age and Interuterine Growth Retardation. Proc. Nutr. Soc., 57, 257-263.

72. McDonald, K.K., Zharikov, S., Block, E.R., and Kilberg, M.S. (1997) A Caveolar Complex between the Cationic Amino Acid Transporter 1 and Endothelial Nitric‑oxide Synthase May Explain the "Arginine Paradox". J. Biol. Chem., 272, 31213-31216.

71. Matthews, J.C., Aslanian, A.M., McDonald, K.K., Yang, W., Malandro, M.S., Novak, D.A., and Kilberg, M.S. (1997) An Expression System for Mammalian Amino Acid Transporters Using a Stably-Maintained Episomal Vector. Anal. Biochem., 254, 208-214.

70. Hyatt, S.L., Aulak, K.S., Malandro, M.S., Kilberg, M.S., and Hatzoglou, M., (1997) Adaptive Regulation of the Cationic Amino Acid Transporter-1 (CAT-1) in Fao Cells. J. Biol. Chem., 272, 19951-19957.

69. Novak, D.A., Matthews, J.C., Beveridge, M.J., Yao, S.Y.M., Young, J., and Kilberg, M.S., (1997) Demonstration of System y⁺L Activity on the Basal Plasma Membrane Surface of Rat Placenta and Developmentally-Regulated Expression of 4F2HC mRNA., Placenta, 18, 643-648.

68. Hutson, R.G., Kitoh, T., Moraga Amador, D., Cosic, S., Schuster, S.M., and Kilberg, M.S. (1997) Amino Acid Control of Asparagine Synthetase: Relation to Asparaginase Resistance in Human Leukemia Cells. Am. J. Physiol., 272, 1691-1699.

67. McDonald, K.K., Rouhani, R., Handlogten, M.E., Block, E.R., Griffith, O.W., Allison, R.D.,and Kilberg, M.S. (1997) Inhibition of Endothelial Cell Transport System y⁺ by Arginine Analogs that Inhibit Nitric Oxide Synthase. Biochim. Biophys. Acta, 1324, 133-141.

66. Tamarappoo, B.K., Raizada, M., and Kilberg, M.S. (1997) Identification of a Novel Na⁺-dependent Glutamine Transporter in Cultured Rat Neurons. J. Neurochem. 68, 954-960.

65. Hutson, R.G., Warskulat, U., Häussinger, D., and Kilberg, M.S. (1996) An Example of Nutrient Control of Gene Expression: Amino Acid-dependent Regulation of Asparagine Synthetase. Clinical Nutrition, 15, 327-331.

64. Malandro, M.S., Beveridge, M.J., Kilberg, M.S., and Novak, D.A., (1996) Effect of Low-Protein Diet-Induced Intrauterine Growth Retardation on Rat Placental Amino acid Transport. Am. J. Physiol., 271, C295-C303.

63. Malandro, M.S., Beveridge, M.J., Novak, D.A., and Kilberg, M.S. (1996) Rat Placental Amino Acid Transport After Protein-Deprivation-Induced Intrauterine Growth Retardation. Biochem. Soc. Trans. 24, 839-843.

62. Handlogten, M.E., Dudenhausen, E.E., Yang, W., and Kilberg, M.S. (1996) Association of Hepatic System A Amino Acid Transporter with the Membrane-Cytoskeletal Proteins Ankyrin and Fodrin. Biochim. Biophys. Acta, 1282, 107-114.

61. Velaz-Faircloth, L., McGraw, T.S., Fremeau, R.T., Jr., Malandro, M.S., Kilberg, M.S., and Anderson, K.J. (1996) Characterization and Distribution of a Neuronal Glutamate Transporter Cloned from Rat Brain. Am. J. Physiol., 270, C67-C75.

60. Tamarappoo, B.K., McDonald, K.K., and Kilberg, M.S. (1996) Expressed Human ASCT1 Hippocampal Amino Acid Transporter Exhibits a pH-Dependent Change in Substrate Specificity. Biochim. Biophys. Acta, 1279, 131-136.

59. Hutson, R.G. and Kilberg, M.S., (1994) Cloning of a Rat Asparagine Synthetase cDNA and Substrate Specificity of the Amino Acid-Dependent Control of Its mRNA Content. Biochem. J., 304, 745-750.

58. Tamarappoo, B.K., Singh, H.P., and Kilberg, M.S. (1994) Protein Modification of Glutamine Transport in SV40-Transformed Hepatocytes and Immunodetection of Proteins Associated with System N Transport Activity. J. Nutr., 124, S1493-1498.

57. Malandro, M.S., Beveridge, M.J., Kilberg, M.S., and Novak, D.A. (1994) Ontogeny of Cationic Amino Acid Transport Systems in Rat Placenta. Am. J. Physiol., 267, C804-811.

56. Novak, D.A., Kilberg, M.S., and Beveridge, M.J. (1994) Ontogeny and Plasma Membrane Localization of Amino Acid Transport System L in Rat Liver., Biochem. J., 301, 671-674.

55. Woodard, M. H., Dunn, W.A., Laine, R. O., Malandro, M., McMahon, R., Simell, O., Block, E.R., and Kilberg, M.S. (1994) Plasma Membrane Clustering of the System y⁺ (CAT-1) Amino Acid Transporter as Detected by Immunohistochemistry. Am. J. Physiol., 266, E817-E824.

54. Laine, R.O., Shay, N.F., and Kilberg, M.S. (1994) Nuclear Retention of the Induced mRNA Following Amino Acid-Dependent Transcriptional Regulation of Mammalian Ribosomal Proteins L17 and S25. J. Biol. Chem. 269, 9693-9697.

53. Chiles, T.C., Laine, R.O., Shay, N., Nick, H.S., Handlogten, M.E., and Kilberg, M.S. (1993) Enhanced mRNA Content in Response to Amino Acid Starvation for a 73 kDa Protein of the Inner Mitochondrial Membrane. Biochem. Biophys. Res. Commun. 193, 1068-1075.

52. Shafqat, S., Tamarappoo, Balaji K., Kilberg, M.S., Puranam, R.S., McNamara, J.O., Guadano-Ferraz, A., and Fremeau, R.T., (1993) Cloning and Expression of a Novel Na⁺-Dependent Neutral Amino Acid Transporter Structurally Related to Mammalian Na⁺/Glutamate Cotransporters. J. Biol. Chem. 268, 15351-15355.

51. Tamarappoo, B.K., Nam, M., Kilberg, M.S., and Welbourne, T.C., (1993) Glucocorticoid Regulation of Splanchnic Glutamine, Alanine, Glutamate, Ammonia, and Glutathione Fluxes. Am. J. Physiol. 264, E526-E533.

50. Cariappa, R. and Kilberg, M.S. (1992) Plasma Membrane Domain Localization, Targeting, and Transcytosis of the Glucagon-Induced Hepatic System A Carrier. Am. J. Physiol. 263, E1021-E1028.

49. Tamarappoo, B.K., Handlogten, M.E., Laine, R.O., Serrano, M.A., Dugan, J., and Kilberg, M.S. (1992) Identification of the Protein Responsible for Hepatic System N Amino Acid Transport Activity. J. Biol. Chem. 267, 2370-2374.

48. Laine, R.O. Laipis, P.J., Shay, N.F., and Kilberg, M.S. (1991) Identification of an Amino Acid-Regulated mRNA (ASI) from Rat Liver as the Mammalian Equivalent of Bacterial Ribosomal Protein L22. J. Biol. Chem., 266, 16969-16972.

47. Wilde, S.W. and Kilberg, M.S., (1991) Glutamine Transport by Basolateral Plasma Membrane Vesicles Prepared from Rabbit Intestine. Biochem. J. 277,687-692.

46. Bode, B.P. and Kilberg, M.S. (1991) Amino Acid-Dependent Increase in Hepatic System N Activity is Linked to Cell Swelling. J. Biol. Chem. 266, 7376-7381.

45. Tamarappoo, B.K. and Kilberg, M.S., (1991) Functional Reconstitution of the Hepatic System N Amino Acid Transport Activity. Biochem. J. 274, 97-101.

44. Shay, N.F., Nick, H.S., and Kilberg, M.S., (1990) Molecular Cloning of an Amino Acid Regulated mRNA (ASI) in Rat Hepatoma Cells. J. Biol. Chem. 265, 17844-17848.

43. Mailliard, M.E. and Kilberg, M.S., (1990) Characterization of Hepatic Amino Acid Transport in Human Liver Plasma Membrane Vesicles. J. Biol. Chem. 265, 14321-14326.

42. Tarnuzzer, R., Campa, M.J., Qian, N.-X., Englesberg, E., and Kilberg, M.S., (1990) Expression of the Mammalian System A Neutral Amino Acid Transporter in Xenopus Oocytes. J. Biol. Chem. 265, 13914-13917.

41. Campa, M. and Kilberg, M.S., (1990) Characterization of Neutral and Cationic Amino Acid Transport in Xenopus Oocytes. J. Cell. Physiol. 141, 645-652.

40. Cariappa, R. and Kilberg, M.S., (1990) Hormone-Induced System A Amino Acid Transport Activity in Rat Liver Plasma Membrane and Golgi Vesicles. Evidence for a Differential Sensitivity to Inactivation by NEM During Carrier Maturation. J. Biol. Chem. 265, 1470-1475.

39. Fong, A. D., Handlogten, M.E., and Kilberg, M.S. (1989) Substrate-Dependent Adaptive Regulation and Trans-Inhibition of System A-Mediated Amino Acid Transport. Studies Using Rat Hepatoma Plasma Membrane Vesicles. Biochim. Biophys. Acta 1022, 325-332.

38. Fafournoux, P., Dudenhausen, E., and Kilberg, M.S., (1989) Solubilization and Reconstitution Characteristics of Hepatic System A-mediated Amino Acid Transport. J. Biol. Chem. 264, 4805-4811.

37. Kilberg, M.S. (1989) Measurement of Amino Acid Transport by Hepatocytes in Suspension and Monolayer Culture. Methods Enzymol. 173, 564-575.

36. Chiles, T.C., Dudeck-Collart, K.L., and Kilberg, M.S. (1988) Inactivation of Amino Acid Transport in Rat Hepatocytes and Hepatoma Cells By PCMBS. Am. J. Physiol. 255, C340-C345.

35. Handlogten, M.E. and Kilberg, M.S. (1988) Growth-Dependent Regulation of System A in SV40-Transformed Fetal Rat Hepatocytes. Am. J. Physiol. 255, C261-C270.

34. Kilberg, M.S. and Handlogten, M.E. (1988) Transport of Branched Chain Amino Acids and Their Corresponding 2-Keto Acids by Mammalian Cells. Methods Enzymol. 166, 252-260.

33. Dudeck, K.L., Dudenhausen, E. E., Chiles, T.C., Fafournoux, P., and Kilberg, M.S., (1987) Evidence for Inherent Differences in the System A Carrier from Normal and Transformed Liver Tissue. Differential Inactivation and Substrate Protection in Membrane Vesicles and Reconstituted Proteoliposomes. J. Biol. Chem. 262, 12565-12569.

32. Chiles, T.C., O'Brien, T.W., and Kilberg, M.S. (1987) Production of Monospecific Antibodies to a Low-Abundance Hepatic Membrane Protein Using Nitrocellulose Immobilized Protein as Antigen. Anal. Biochem. 163, 136-142.

31. Bracy, D.S., Schenerman, M.A., and Kilberg, M.S. (1987) Solubilization and Reconstitution of Hepatic System A-mediated Transport: Preparation of Proteoliposomes Containing Glucagon-Stimulated Transport Activity. Biochim. Biophys. Acta 899, 51-58.

30. Chiles, T.C. and Kilberg, M.S. (1986) System A Transport Activity in Normal Rat Hepatocytes and Transformed Liver Cells: Substrate Protection from Inactivation by Sulfhydryl-Modifying Reagents. J. Cell. Physiol. 129, 321-328.

29. Kilberg, M.S., Bracy, D.S. and Handlogten, M.E. (1986) Substrate Regulation of Hepatic System A Transport Activity Following Induction by Substrate Starvation or Glucagon. Fed. Proc. 45, 2438-2454.

28. Schenerman, M.A. and Kilberg, M.S. (1986) Maintenance of Glucagon-Stimulated System A Amino Acid Transport Activity in Rat Liver Plasma Membrane Vesicles. Biochim. Biophys. Acta 856, 428-436.

27. Bracy, D.S., Handlogten, M.E., Barber, E.F., Han, H.-P. and Kilberg, M.S. (1986) cis-Inhibition, trans-Inhibition and Repression of Hepatic Amino Acid Transport Mediated by System A. Substrate Specificity and Other Properties. J. Biol. Chem. 261, l514-1520.

26. Handlogten, M.E., Barber, E.F., Bracy, D.S. and Kilberg, M.S. (1985) Amino Acid-Dependent Inactivation of Glucagon-Induced System A Transport Activity in Cultured Rat Hepatocytes. Mol. Cell. Endocrin. 43, 61-69.

25. Gardner, D.F., Kilberg, M.S., Wolfe, M.M., Buynitzkey, S.J. and Misbin, R.I. (1985) Preferential Binding of Vasoactive Intestinal Peptide to Hepatic Nonparenchymal Cells. Am. J. Physiol. 248, G663-G669.

24. Bannai et al (1984) Amino Acid Transport Systems. Neurochem. Res. 9, 1757-1758.

23. Bannai et al (1984) Amino Acid Transport Systems. Nature 311, 308.

22. Kilberg, M.S., Han, H.-P., Barber, E.F. and Chiles, T.C. (1985) Adaptive Regulation of Neutral Amino Acid Transport System A in Rat H4 Hepatoma Cells. J. Cell. Physiol. 122, 290-298.

21. Weissbach, L. and Kilberg, M.S. (1984) Amino Acid-Activation of Amino Acid Transport System N Early in Primary Cultures of Rat Hepatocytes. J. Cell. Physiol. 121, 1313-1318.

20. Handlogten, M.E. and Kilberg, M.S. (1984) Induction and Decay of Amino Acid Transport in the Liver. Turnover of Transport Activity in Isolated Hepatocytes After Stimulation by Diabetes or Glucagon. J. Biol. Chem. 259, 3519-3525.

19. Barber, E.F., Handlogten, M.E. and Kilberg, M.S. (1983) Induction of Amino Acid Transport System A in Rat Hepatocytes is Blocked by Tunicamycin. J. Biol. Chem. 258, 11851-11855.

18. Kilberg, M.S. and Gwynn, M.B. (1983) Plasma Membrane Transport of 2-Ketoisocaproate by Rat Hepatocytes in Primary Culture. J. Biol. Chem. 258, 11524-11527.

17. Kilberg, M.S., Vida, T.A. and Barber, E.F. (1983) Regulation of Neutral Amino Acid Transport in Hepatocytes Isolated from Adrenalectomized Rats. J. Cell. Physiol. 114, 45-52.

16. Barber, E.F., Handlogten, M.E., Vida, T.A. and Kilberg, M.S. (1982) Neutral Amino Acid Transport in Hepatocytes Isolated from Streptozotocin-induced Diabetic Rats. J. Biol. Chem. 257, 14960-14967.

15. Weissbach, L., Handlogten, M.E., Christensen, H.N. and Kilberg, M.S. (1982) Evidence for Two Na⁺-independent Neutral Amino Acid Transport Systems in Primary Cultures of Rat Hepatocytes. Time-Dependent Changes in Activity. J. Biol. Chem. 257, 12006-12011.

14. Handlogten, M.E. and Kilberg, M.S. (1982) Transport System A is Not Responsive to Hormonal Stimulation in Primary Cultures of Fetal Rat Hepatocytes. Biochem. Biophys. Res. Commun. 108, 1113-1119.

13. Handlogten, M.E., Weissbach, L. and Kilberg, M.S. (1982) Heterogeneity of Na⁺-independent 2-Aminobicyclo-(2,2,l)-heptane-2-carboxylic Acid and L-Leucine Transport in Isolated Rat Hepatocytes in Primary Culture. Biochem. Biophys. Res. Commun. 104, 307-313.

12. Handlogten, M.E., Kilberg, M.S. and Christensen, H.N. (1982) Incomplete Correspondence Between Repressive and Substrate Action by Amino Acids on Transport Systems A and N in Monolayered Rat Hepatocytes. J. Biol. Chem. 257, 345-348.

11. Shotwell, M.A., Jayme, D.W., Kilberg, M.S. and Oxender, D.L. (1981) Neutral Amino Acid Transport Systems in Chinese Hamster Ovary Cells. J. Biol. Chem. 256, 5422-5427.

10. Kilberg, M.S., Handlogten, M.E. and Christensen, H.N. (1981) Characterization of System ASC in Isolated Rat Hepatocytes. J. Biol. Chem. 256, 3304-3312.

9. Kilberg, M.S., Handlogten, M.E. and Christensen, H.N. (1980) Characteristics of an Amino Acid Transport System in Rat Liver for Glutamine, Asparagine, Histidine, and Closely Related Analogs. J. Biol. Chem. 255, 4011-4019.

8. Ohsawa, M., Kilberg, M.S., Kimmel, G. and Christensen, H.N. (1980) Energization of Amino Acid Transport in Energy-Depleted Ehrlich Cells and Plasma Membrane Vesicles. Biochim. Biophys. Acta 599, 175-190.

7. Kilberg, M.S. and Christensen, H.N. (1980) The Relationship Between Membrane Potential and the Transport Activity of Systems A and L in Ehrlich Cell Plasma Membrane Vesicles. Memb. Biochem. 3, 155-168.

6. Kilberg, M.S., Christensen, H.N. and Handlogten, M.E. (1979) Cysteine as a System-Specific Substrate for Transport System ASC in Rat Hepatocytes. Biochem. Biophys. Res. Commun. 88, 744-751.

5. Kilberg, M.S. and Christensen, H.N. (1979) Electron-Transferring Enzymes in the Plasma Membrane of the Ehrlich Ascites Tumor Cell. Biochemistry 18, 1525-1530.

4. Kilberg, M.S. and Neuhaus, O.W. (1978) Hormonal Control of Amino Acid Transport in the Liver of Rats Exposed to Whole-Body Irradiation. Radiat. Res. 73, 360-372.

3. Kilberg, M.S. and Neuhaus, O.W. (1977) Hormonal Regulation of Hepatic Amino Acid Transport. J. Supramol. Structure 6, 191-204.

2. Kilberg, M.S. and Neuhaus, O.W. (1976) The Role of Stimulated Amino Acid Transport in Promoting Glycogenesis in the Irradiated Rat. Radiat. Res. 66, 597-608.

1. Kilberg, M.S. and Neuhaus, O.W. (1975) Accumulation of 2-Aminoisobutyric Acid by Rat Tissues following Whole-Body Irradiation. Radiat. Res. 64, 546-554.

INVITED REVIEWS:

Richards, N. G.J. and Kilberg, M.S. (2006) Asparagine Synthetase Chemotherapy. Annu. Rev. Biochem., 75, 629-654.

Kilberg, M.S., Chen, H., Leung-Pineda, V., and Pan, Y.-X. (2005) Amino Acid Control of Gene Expression in Mammalian Cells. Annu. Rev. Nutr., 25, 59-85.

Barbosa-Tessmann, I., Chen, C., Zhong, C., and Kilberg, M.S. (2002) Genomic Sequences Necessary for Transcriptional Activation by Amino Acid Deprivation of Mammalian Cells, J. Nutr., 132, 1801-1804.

Malandro, M.S. and Kilberg, M. S. (1996) Molecular Biology of Mammalian Amino Acid Transporters. Annu. Rev. Biochem., 65, 305-336.

Laine, R.O., Hutson, R.G., and Kilberg, M.S. (1996) Eukaryotic Gene Expression: Metabolite Control by Amino Acids. Prog. Nuc. Acid Res. and Mol. Biol., 53, 219-248.

Christensen, H.N. and Kilberg, M.S. (1995) Hepatic Amino Acid Transport Primary to the Urea Cycle in Regulation of Biologic Neutrality. Nutrition Rev., 53, 74-76.

Kilberg, M.S., Hutson, R.G., and Laine, R.O. (1994) Amino Acid-Regulated Gene Expression in Eukaryotic Cells. FASEB J. 8, 13-19.

Kilberg, M.S., Stevens, B.R., and Novak, D.A. (1993) Recent Advances in Mammalian Amino Acid Transport. Annu. Rev. Nutr. 13, 137-165.

Bode, B., Tamarappoo, B.K., Mailliard, M., and Kilberg, M.S. (1990) Characteristics and Regulation of Hepatic Glutamine Transport. J. Paren. Enteral Nutr. 14, 51S-55S.

Kilberg, M.S. (1986) System A-Mediated Amino Acid Transport: Metabolic Control at the Plasma Membrane. Trends Biochem. Sci., 11, 183-186.

Kilberg, M.S., Barber, E.F. and Handlogten, M.E. (1985) Characteristics and Hormonal Regulation of Amino Acid Transport System A in Isolated Rat Hepatocytes. Curr. Topics Cell. Regul. 25, 133-163.

Shotwell, M.A., Kilberg, M.S. and Oxender, D.L. (1983) The Regulation of Amino Acid Transport in Mammalian Cells. Biochim. Biophys. Acta, Reviews on Biomembranes, 737, 267-284.

Kilberg, M.S. (1982) Amino Acid Transport in Isolated Rat Hepatocytes. J. Memb. Biol. 69, l-12.

BOOK CHAPTERS / MONOGRAPHS:

Kilberg, M.S., Zhong, C., McClellan, R., and Pan, Y. (2004) Transcriptional regulatory mechanisms for the response to amino acid deprivation of mammalian cells. In, “Nutrient-Induced Responses in Eukaryotic Cells”, Topics in Current Genetics, (Winderickx, J. and Taylor, P.M, eds), Springer Verlag, Berlin, pp. 5-24.

Kilberg, M.S., Leung-Pineda, V., and Chen, C. (2003) Amino Acid-Dependent Control of Transcription in Mammalian Cells, In, “Molecular Nutrition”, ( Daniel H. and Zempleni, J., eds), CABI Publishing, Wallington, U.K., pp. 105-119.

Haussinger, D. and Kilberg, M.S. (1992) Amino Acid Transport in the Liver., In "Mammalian Amino Acid Transport: Mechanisms and Control", (Kilberg, M. and Häussinger, D., eds), Plenum Press, N.Y., pp.133-148.

Lang, F., Haussinger, D., and Kilberg, M.S. (1992) Amino Acid Transport: Relation to Cell Volume and Cell Growth, In, "Mammalian Amino Acid Transport: Mechanisms and Control", (Kilberg, M. and Häussinger, D., eds), Plenum Press, pp. 113-130.

Kilberg, M.S., (1989) Regulation of Hepatic Amino Acid Transport and Partial Purification of the System A Carrier., In , "Hepatic Transport of Organic Solutes, (Petzinger, E., Kinne, R., and Sies, H., eds), Springer-Verlag, Berlin, pp. 167-176.

Christensen, H.N. and Kilberg, M.S. (1987) Amino Acid Transport Across the Plasma Membrane: Role of Regulation in Interorgan Flows., In, Physiological Society Study Guides, Manchester University Press, Manchester, U.K., pp. 10-46.

Kilberg, M.S., Weissbach, L. and Barber, E.F. (1983) Changes in Amino Acid Transport in Primary Cultures of Adult Rat Hepatocytes. In, Isolation, Characterization and Use of Hepatocytes, (Harris, R.A. and Cornell, N.W., eds), Elsevier, New York, pp. 227-232.

Kilberg, M.S. and Neuhaus, O.W. (1978) Hormonal Regulation of Hepatic Amino Acid Transport. In, "Molecular Aspects of Membrane Transport". A.R. Liss, New York, pp. 117-130.