Dr. Nancy Denslow

Contents

*   Work Information

*   Favorite Links

*   Contact Information

*   Current Projects

*   Biographical Information

Work Information

Scientist, Department of Biochemistry and Molecular Biology, University of Florida

Scientific Director, Protein Chemistry and Molecular Biomarkers Facilities, Biotechnology Program

            The Biotechnology Program at the University of Florida has been set up to give state-of-the-art support to research projects within the state of Florida.  For more information about the specific services offered, please see our web page at WWW.biotech.ufl.edu

Research Areas

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  1. Proteomics:  Identify proteins from 2D gels and characterize phosphorylation and other post-translation modifications in proteins by mass spectrometry.
  2. Biomarkers:  Develop biomarkers of exposure and effect for environmental contaminants that behave as hormones.
  3. Mechanistic  Studies:  Understand the pathways by which environmental contaminants perturb normal physiology.

 

Personal Research Interests

I am interested in understanding the mechanisms by which environmental contaminants affect wildlife.  In particular, I am interested in contaminants that mimic steroid hormones as these target reproduction and development. 

 

My laboratory focuses on altered gene expression in fish that are exposed to contaminants.  We have developed several biomarkers that can be used to follow changes at the molecular level including monoclonal antibodies for the detection of vitellogenin and molecular probes for the detection of differentially expressed mRNAs.   These changes are correlated with changes in physiological function.

 

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Links to the Facilities

*   http://www.biotech.ufl.edu/ProteinChem/ -- Protein Chemistry Core

*   http://www.biotech.ufl.edu/MolecularBiomarkers/ -- BEECS Molecular Biomarkers

 

 

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Contact Information

Interdisciplinary Center for Biotechnology Research – ICBR or

Department of Biochemistry and Molecular Biology

PO Box 100156 HC

Gainesville, FL 32610

 

Office: MSB MG-42

E-mail address

denslow@biotech.ufl.edu

Web address

WWW.biotech.ufl.edu/ProteinChem/

Office phone/ Fax

Phone: (352)392-9665

 

Fax: (352)392-4441

 

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Current Projects

*   Preparation and use of cDNA microarrays for fish – FishN’Chips

*   Determination of Function of Estrogen Receptors

*   Studies on Environmental Contaminants

 

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Biographical Information

 

Educational Background

           

BS in Chemistry (with honors) --  Mary Washington College, Fredericksburg, VA

MS in Biochemistry --                   Yale University

Ph.D. in Biochemistry--                University of Florida

 

 

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Last revised: 9/4/99