The laboratory studies viral, mitochondrial, and mammalian molecular genetics. Current research includes: cloning and site-directed mutagenesis of the functional isoforms of carbonic anhydrase (with David Silverman); function and regulation of phenylalanine hydroxylase; in vitro models of adeno-associated virus DNA replication and integration (with Kenneth Berns); and development of AAV-based vectors for gene therapy .

M.D. 1966, Johns Hopkins University
Ph.D. 1964, Biochemistry, Johns Hopkins University br>B.A. 1960, Biology, Johns Hopkins University

Studies of adeno-associated virus, its replication in vivo and in vitro, and applications of these studies to the construction of vectors for gene therapy.

Nenita Cortez
B.S. 1959, Pharmacy, University of the Philippines

Eukaryotic cell culture specialist.

Ph.D. 1968, Physical Chemistry, Columbia University
B.S. 1964, Chemistry, Michigan State University

Studies of the catalytic mechanisms of carbonic anhydrase, using site- directed mutants to study the role of specific amino acid residues in catalysis and proton transfer.

Hiqian An, Ph.D.
Ph.D. 1998, Molecular Biology and Biochemistry, Peking Union Medical College & Chinese Academy of Medical Science
B.S. 1987, Biology, Hebei University

Mutagenesis studies of carbonic anhydrase.

John Alexander
B.S. 1999, Microbiology and Cell Science, University of Florida

Mutagenesis studies of human phenylalanine hydroxylase (PAH).

Rami Heidami
B.S. 1999, Microbiology and Cell Science, University of Florida

Mutagenesis studies of human carbonic anhydrase III.

Heather Steele
B.S. 1998, Education, Central Michigan University

Mutagenesis studies of human carbonic anhydrase II.

Thomas Wingo
B.S. 1999, Biochemistry and Molecular Biology, University of Florida

Mutagenesis studies of human carbonic anhydrase IX. 

Jon-Michael Knapp
B.S. 2002, Chemistry, University of Florida