RESEARCH FACULTY MEMBER
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Yi Zhang, Ph.D. Assoc.in Pharmacology (with Dr. Scarpace) Phone: 352-376-1611 ext. 5046 Office:E586 VAMC Email: yzhang@ufl.edu Publications: Search PubMed |
RESEARCH INTERESTS
My research focuses on leptin signal transduction in hypothalamus of an aging rat model, mechanisms of leptin resistance and the association between leptin resistance and obesity. The ultimate goal of this line of research is to understand how humans gain weight and to develop innovative strategies that will not only produce weight loss but also help maintain the weight reduction. Studies of interest involve leptin regulation of neuropeptide gene expression, leptin receptor analysis and leptin receptor-mediated signal transduction. The major means of intervention is the central gene therapy combined with traditional pharmacological drug administration. Data collection includes assessment of both physiological and metabolic parameters such as animal body weight, food intake, whole body oxygen consumption, serum/plasma hormone profile, uncoupling protein 1, 2, 3 expression and protein levels in white and brown adipose tissues, palmitate oxidation rate in skeletal muscle and hypothalamic neuropeptide mRNA and protein levels.
| Dr. Afzal | Dr. Erdos | Dr. King | Dr. Law | Dr. Shapiro | Dr. Shaw |
| Dr. Soti | Dr. Tu | Dr. Xing | Dr. Zhang | Dr. Zuo |
Location: http://www.med.ufl.edu/pharm/res_joint/zhang.shtml