Himangshu S. Bose, Ph.D. Assistant Professor (352) 392-3243 (Office) (352) 392-2452 (Lab) hbose@ufl.edu Office: M554B Lab: M557 Publications: Search PubMed

My laboratory is focused on the folding and translocation of mitochondrial proteins that regulate steroid hormone synthesis.

Among the proteins imported into mitochondria are enzymes that convert cholesterol into steroid hormones. The steroidogenic acute regulatory protein (StAR) facilitates the movement of cholesterol from the outer to inner mitochondrial membrane. Human StAR mutations cause a lethal disorder of steroidogenesis. StAR's action is confined to the outer mitochondrial membrane (OMM); in fact, the degree of StAR activity is proportional to the time it resides on the OMM. My laboratory's goal is to characterize StAR's entry into mitochondria: to understand StAR's docking with the OMM, to determine whether it enters the mitochondria through a non-classic import mechanism, to identify proteins involved in that mechanism and to characterize how StAR enters. In addition we seek to understand how StAR binds to, imports, and discharges cholesterol, and how the process of StAR-mediated cholesterol import is related to StAR's protein import.

Background:

Ph.D. (Biophysics) - Protein-Nucleic acid interaction
Postdoctoral training - Cell Biology of Endocrine disorder

Personal:

Hobbies: Ancient History; Playing chess and cards

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Last updated on May 2, 2005.